Article

Dynamic hotspots in the Uba7 UFD direct UbcH8 recognition

2025-06-19

Abstract excerpt

The ISGylation pathway, a key post-translational modification, plays a pivotal role in the innate immune response by covalently attaching ISG15 to target proteins. This cascade involves a series of enzymatic steps, including activation by the E1 enzyme Uba7, conjugation by the E2 enzyme UbcH8, and ligation by an E3 ligase. Central to this process is the ubiquitin-fold domain (UFD) of Uba7, which facilitates the tr...

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Literature Corpus work: 3d9649bb-0daa-54db-b261-a1f27ebd85b5
DOI: 10.1101/2025.06.14.659664

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