Article
Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies.
American journal of human genetics - 7 Oct 2011
Denny Joshua C, Crawford Dana C, Ritchie Marylyn D, Bielinski Suzette J, Basford Melissa A, Bradford Yuki, Chai High Seng, Bastarache Lisa, Zuvich Rebecca, Peissig Peggy, Carrell David, Ramirez Andrea H, Pathak Jyotishman, Wilke Russell A, Rasmussen Luke, Wang Xiaoming, Pacheco Jennifer A, Kho Abel N, Hayes M Geoffrey, Weston Noah, Matsumoto Martha, Kopp Peter A, Newton Katherine M, Jarvik Gail P, Li Rongling, Manolio Teri A, Kullo Iftikhar J, Chute Christopher G, Chisholm Rex L, Larson Eric B, McCarty Catherine A, Masys Daniel R, Roden Dan M, de Andrade Mariza
Abstract excerpt
We repurposed existing genotypes in DNA biobanks across the Electronic Medical Records and Genomics network to perform a genome-wide association study for primary hypothyroidism, the most common thyroid disease. Electronic selection algorithms incorporating billing codes, laboratory values, text queries, and medication records identified 1317 cases and 5053 controls of European ancestry within five electronic...
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