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Article

Real-Time Characterization of Clonal Fate Decisions in Complex Leukemia Samples by Fluorescent Genetic Barcoding.

Cells - 14 Dec 2022

Maetzig Tobias, Lieske Anna, Dörpmund Nicole, Rothe Michael, Kleppa Marc-Jens, Dziadek Violetta, Hassan Jacob Jalil, Dahlke Julia, Borchert Dorit, Schambach Axel

Abstract excerpt

Clonal heterogeneity in acute myeloid leukemia (AML) forms the basis for treatment failure and relapse. Attempts to decipher clonal evolution and clonal competition primarily depend on deep sequencing approaches. However, this prevents the experimental confirmation of the identified disease-relevant traits on the same cell material. Here, we describe the development and application of a complex fluorescent...

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PMID: 36552809
DOI: 10.3390/cells11244045
PMCID: PMC9776743

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