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Article

The clones have STRACK: Tracing responses to leukemic mutations.

Cell stem cell - 3 Apr 2025

Papapetrou Eirini P

Abstract excerpt

Rodriguez-Fraticelli and colleagues combine genetic barcoding with ex vivo expansion and sister-cell analysis of murine hematopoietic stem cells (HSCs) carrying inducible leukemia driver mutations. This approach allows them to capture the intrinsic heterogeneity of clonal cell behaviors and study how these impact cell fates upon acquisition of leukemia driver mutations.

Read the complete abstract on PubMed

Topics

Animals
Mutation
Leukemia
Clone Cells
Mice
Hematopoietic Stem Cells
Humans

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Identifiers

PMID: 40185067
DOI: 10.1016/j.stem.2025.03.001

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