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Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia

10 May 2017

Abstract excerpt

High frequencies of blasts in primary acute lymphoblastic leukaemia (ALL) samples have the potential to induce leukaemia and to engraft mice. However, it is unclear how individual ALL cells each contribute to drive leukaemic development in a bulk transplant and the extent to which these blasts vary functionally. We used cellular barcoding as a fate mapping tool to track primograft ALL blasts in vivo. Our results...

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PMID: 28487542
DOI: 10.1038/leu.2017.140

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