Article
Prothrombin deficiency results in embryonic and neonatal lethality in mice.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 1998
Sun W Y, Witte D P, Degen J L, Colbert M C, Burkart M C, Holmbäck K, Xiao Q, Bugge T H, Degen S J
Abstract excerpt
The conversion of prothrombin (FII) to the serine protease, thrombin (FIIa), is a key step in the coagulation cascade because FIIa triggers platelet activation, converts fibrinogen to fibrin, and activates regulatory pathways that both promote and ultimately suppress coagulation. However, several observations suggest that FII may serve a broader physiological role than simply stemming blood loss, including the...
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