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Article

Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura.

Blood - 15 Apr 2006

Banno Fumiaki, Kokame Koichi, Okuda Tomohiko, Honda Shigenori, Miyata Shigeki, Kato Hisashi, Tomiyama Yoshiaki, Miyata Toshiyuki

Abstract excerpt

ADAMTS13 is a plasma metalloproteinase that regulates platelet adhesion and aggregation through cleavage of von Willebrand factor (VWF) multimers. In humans, genetic or acquired deficiency in ADAMTS13 causes thrombotic thrombocytopenic purpura (TTP), a condition characterized by thrombocytopenia and hemolytic anemia with microvascular platelet thrombi. In this study, we report characterization of mice bearing a...

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Source

Identifiers

PMID: 16368888
DOI: 10.1182/blood-2005-07-2765

Genes

ADAMTS13
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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