Article
Role of p53 in the progression of gastric cancer.
Oncotarget - 15 Dec 2014
Busuttil Rita A, Zapparoli Giada V, Haupt Sue, Fennell Christina, Wong Stephen Q, Pang Jia-Min B, Takeno Elena A, Mitchell Catherine, Di Costanzo Natasha, Fox Stephen, Haupt Ygal, Dobrovic Alexander, Boussioutas Alex
Abstract excerpt
Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer (GC) but is poorly described in terms of molecular changes. Here, we explored the role of TP53, a commonly mutated gene in GC, to determine if p53 protein expression and/or the presence of somatic mutations in TP53 can be used as a predictive marker for patients at risk of progressing to GC from IM. Immunohistochemistry and high...
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