Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection.

Gastroenterology - 1 Aug 2014

Shimizu Takahiro, Marusawa Hiroyuki, Matsumoto Yuko, Inuzuka Tadashi, Ikeda Atsuyuki, Fujii Yosuke, Minamiguchi Sachiko, Miyamoto Shin'ichi, Kou Tadayuki, Sakai Yoshiharu, Crabtree Jean E, Chiba Tsutomu

Abstract excerpt

BACKGROUND & AIMS: Helicobacter pylori infection is a risk factor for gastric cancer. To explore the genetic basis of gastric cancer that develops in inflamed gastric mucosa, we investigated genetic aberrations that latently accumulate in nontumorous gastric epithelium with H pylori infection. METHODS: We performed whole-exome sequencing of gastric tumors, noncancerous tissues with gastritis, and peripheral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exome
Share to Gastric Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastritis

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to Mice, 129 Strain

Share to Precancerous Conditions

Share to Stomach Neoplasms

Source

Identifiers

PMID: 24786892
DOI: 10.1053/j.gastro.2014.04.036

Genes

AICDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection.PMID 24786892Read ↗

Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer.Semantic proximity Read ↗

Mutational analysis by next generation sequencing of gastric type dysplasia occurring in hyperplastic polyps of the stomach: Mutations in gastric hyperplastic polyps.Semantic proximity Read ↗

The somatic mutation landscape of normal gastric epithelium.Semantic proximity Read ↗

Evaluation of Tumor DNA Sequencing Results in Patients with Gastric and Gastroesophageal Junction Adenocarcinoma Stratified by TP53 Mutation Status.Semantic proximity Read ↗

Cancers of the upper gastro-intestinal tract: a review of somatic mutation distributions.Semantic proximity Read ↗

Distinct genomic profile in h. pylori ‐associated gastric cancerSemantic proximity Read ↗

Fusobacterium Nucleatum-Induced Tumor Mutation Burden Predicts Poor Survival of Gastric Cancer PatientsSemantic proximity Read ↗

APOBEC3A drives deaminase mutagenesis in human gastric epithelium.Semantic proximity Read ↗

Cancer-associated SNPs in bacteria: lessons from Helicobacter pylori.Semantic proximity Read ↗

The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas.Semantic proximity Read ↗

Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas.Semantic proximity Read ↗

The somatic mutation landscape of normal gastric epitheliumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.