High-throughput mutation profiling identifies novel molecular dysregulation in high-grade intraepithelial neoplasia and early gastric cancers.

doi:10.1007/s10120-013-0315-1

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Article

High-throughput mutation profiling identifies novel molecular dysregulation in high-grade intraepithelial neoplasia and early gastric cancers.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jan 2014

Fassan Matteo, Simbolo Michele, Bria Emilio, Mafficini Andrea, Pilotto Sara, Capelli Paola, Bencivenga Maria, Pecori Sara, Luchini Claudio, Neves Diogo, Turri Giona, Vicentini Caterina, Montagna Licia, Tomezzoli Anna, Tortora Giampaolo, Chilosi Marco, De Manzoni Giovanni, Scarpa Aldo

Abstract excerpt

BACKGROUND: There is still no widely accepted molecular marker available to distinguish between gastric high-grade intraepithelial neoplasia (HG-IEN) and invasive early gastric cancer (EGC). METHODS: HG-IEN and EGC lesions coexisting in the same patient were manually microdissected from a series of 15 gastrectomies for EGC; 40 ng DNA was used for multiplex PCR amplification using the Ion AmpliSeq Cancer Panel,...

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PMID: 24272205
DOI: 10.1007/s10120-013-0315-1

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APC
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STK11
FGFR3
IDH2
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