Article
Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells.
Oncotarget - 1 Jan 2015
Shiraishi Takumi, Verdone James E, Huang Jessie, Kahlert Ulf D, Hernandez James R, Torga Gonzalo, Zarif Jelani C, Epstein Tamir, Gatenby Robert, McCartney Annemarie, Elisseeff Jennifer H, Mooney Steven M, An Steven S, Pienta Kenneth J
Abstract excerpt
The ability of a cancer cell to detach from the primary tumor and move to distant sites is fundamental to a lethal cancer phenotype. Metabolic transformations are associated with highly motile aggressive cellular phenotypes in tumor progression. Here, we report that cancer cell motility requires increased utilization of the glycolytic pathway. Mesenchymal cancer cells exhibited higher aerobic glycolysis compared...
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