Article

Androgen receptor inhibition induces metabolic reprogramming and increased reliance on oxidative mitochondrial metabolism in prostate cancer

2022-06-01

Abstract excerpt

Prostate cancer cells that survive clinical androgen receptor (AR) blockade mediate disease progression and lethality. Reprogrammed metabolic signaling is one mechanism by which tumor cells can survive treatment. However, how AR inhibition reprograms metabolism, and whether altered metabolism can be exploited to eradicate cells that survive AR blockade, remains unclear. Here, we comprehensively characterized the e...

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Literature Corpus work: 3c1ad7e7-96ad-5bfd-bfae-1f71ebac4c63
DOI: 10.1101/2022.05.31.494200

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