Article

Mitochondrial metabolism sustains CD8 <sup>+</sup> T cell migration for an efficient infiltration into solid tumors

2024-01-15

Abstract excerpt

The ability of CD8 + T cells to infiltrate solid tumors and reach cancer cells is associated with improved patient survival and responses to immunotherapy. Thus, identifying the factors controlling T cell migration in tumors is critical, so that strategies to intervene on these targets can be developed. Although interstitial motility is a highly energy-demanding process, the metabolic requirements of CD8 + T cel...

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Literature Corpus work: d38f97e1-650d-5ea9-b8e2-285bf439fc23
DOI: 10.1101/2024.01.12.575327

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