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The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities

30 Oct 2024

Abstract excerpt

Glycolytic metabolism generates energy and intermediates for biomass production. Tumor-associated glycolysis is upregulated compared to normal tissues in response to tumor cell-autonomous or non-autonomous stimuli. The consequences of this upregulation are twofold. First, the metabolic effects of glycolysis become predominant over those mediated by oxidative metabolism. Second, overexpressed components of the...

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PMID: 39476482
DOI: 10.1016/j.neo.2024.101076

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