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Article

MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer

1 Oct 2023

Abstract excerpt

Advanced prostate cancers are treated with therapies targeting the androgen receptor (AR) signaling pathway. While many tumors initially respond to AR inhibition, nearly all develop resistance. It is critical to understand how prostate tumor cells respond to AR inhibition in order to exploit therapy-induced phenotypes prior to the outgrowth of treatment-resistant disease. Here, we comprehensively characterize the...

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PMID: 37815914
DOI: 10.1016/j.celrep.2023.113221

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