Article
A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy.
The Journal of pathology - 1 Aug 2015
Pertega-Gomes Nelma, Felisbino Sergio, Massie Charlie E, Vizcaino Jose R, Coelho Ricardo, Sandi Chiranjeevi, Simoes-Sousa Susana, Jurmeister Sarah, Ramos-Montoya Antonio, Asim Mohammad, Tran Maxine, Oliveira Elsa, Lobo da Cunha Alexandre, Maximo Valdemar, Baltazar Fatima, Neal David E, Fryer Lee G D
Abstract excerpt
Metabolic adaptation is considered an emerging hallmark of cancer, whereby cancer cells exhibit high rates of glucose consumption with consequent lactate production. To ensure rapid efflux of lactate, most cancer cells express high levels of monocarboxylate transporters (MCTs), which therefore may constitute suitable therapeutic targets. The impact of MCT inhibition, along with the clinical impact of altered...
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