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Article

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

1 Dec 2009

Abstract excerpt

Here, we propose a new model for understanding the Warburg effect in tumor metabolism. Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) in neighboring stromal fibroblasts. These cancer-associated fibroblasts, then undergo myo-fibroblastic differentiation, and secrete lactate and pyruvate (energy metabolites resulting from aerobic glycolysis). Epithelial cancer cells...

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PMID: 19923890
DOI: 10.4161/cc.8.23.10238

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