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Article

Vav1 as a central regulator of invadopodia assembly.

Current biology : CB - 6 Jan 2014

Razidlo Gina L, Schroeder Barbara, Chen Jing, Billadeau Daniel D, McNiven Mark A

Abstract excerpt

Invadopodia are protrusive structures used by tumor cells for degradation of the extracellular matrix to promote invasion [1]. Invadopodia formation and function are regulated by cytoskeletal-remodeling pathways and the oncogenic kinase Src. The guanine nucleotide exchange factor Vav1, which is an activator of Rho family GTPases, is ectopically expressed in many pancreatic cancers, where it promotes tumor cell...

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Identifiers

PMID: 24332539
DOI: 10.1016/j.cub.2013.11.013
PMCID: PMC3917499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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