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Article

Association of Bcr-Abl with the Proto-oncogene Vav Is Implicated in Activation of the Rac-1 Pathway

1 Apr 2002

Abstract excerpt

Vav is a guanine nucleotide exchange factor for the Rho/Rac family predominantly expressed in hematopoietic cells and implicated in cell proliferation and cytoskeletal organization. The oncogenic tyrosine kinase Bcr-Abl has been shown to activate Rac-1, which is important for Bcr-Abl induced leukemogenesis. Previous studies by Matsuguchi et al. (Matsuguchi, T., Inhorn, R. C., Carlesso, N., Xu, G., Druker, B., and...

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Identifiers

PMID: 11790798
DOI: 10.1074/jbc.m112397200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Association of Bcr-Abl with the Proto-oncogene Vav Is Implicated in Activation of the Rac-1 PathwayPMID 11790798Read ↗

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.Semantic proximity Read ↗

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Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins.Semantic proximity Read ↗

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.Semantic proximity Read ↗

Structural determinants for the biological activity of Vav proteins.Semantic proximity Read ↗

The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling.Semantic proximity Read ↗

Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.Semantic proximity Read ↗

Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.Semantic proximity Read ↗

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.Semantic proximity Read ↗

Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Semantic proximity Read ↗

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