Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New insights into the Vav1 activation cycle in lymphocytes.

Cellular signalling - 1 May 2018

Barreira María, Rodríguez-Fdez Sonia, Bustelo Xosé R

Abstract excerpt

Vav1 is a hematopoietic-specific Rho GDP/GTP exchange factor and signaling adaptor. Although these activities are known to be stimulated by direct Vav1 phosphorylation, little information still exists regarding the regulatory layers that influence the overall Vav1 activation cycle. Using a collection of cell models and activation-mimetic Vav1 mutants, we show here that the dephosphorylated state of Vav1 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Jurkat Cells
Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phospholipase C gamma

Share to Phosphoproteins

Share to Proto-Oncogene Proteins c-vav

Share to T-Lymphocytes

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 29410283
DOI: 10.1016/j.cellsig.2018.01.026
PMCID: PMC7615736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New insights into the Vav1 activation cycle in lymphocytes.PMID 29410283Read ↗

Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.Semantic proximity Read ↗

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.Semantic proximity Read ↗

Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.Semantic proximity Read ↗

Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.Semantic proximity Read ↗

Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.Semantic proximity Read ↗

Function of the nucleotide exchange activity of vav1 in T cell development and activation.Semantic proximity Read ↗

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.Semantic proximity Read ↗

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.Semantic proximity Read ↗

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.Semantic proximity Read ↗

Mutation of Vav1 adaptor region reveals a new oncogenic activation.Semantic proximity Read ↗

Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Semantic proximity Read ↗

Structural determinants for the biological activity of Vav proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.