Article
Phenotype of TPBG Gene Replacement in the Mouse and Impact on the Pharmacokinetics of an Antibody-Drug Conjugate.
Molecular pharmaceutics - 1 Jun 2015
Hu George, Leal Mauricio, Lin Qingcong, Affolter Timothy, Sapra Puja, Bates Brian, Damelin Marc
Abstract excerpt
The use of predictive preclinical models in drug discovery is critical for compound selection, optimization, preclinical to clinical translation, and strategic decision-making. Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. In this...
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