Article
A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals - 1 May 2010
Cai Hongliang, Nguyen Nghia, Peterkin Vincent, Yang Young-Sun, Hotz Kathy, La Placa Deirdre Beaton, Chen Shujuan, Tukey Robert H, Stevens Jeffrey C
Abstract excerpt
Humanized mice that express the human UDP-glucuronosyltransferase (UGT) 1 locus have been developed in a Ugt1-null background as a model to improve predictions of human UGT1A-dependent drug clearance. Enzyme kinetic parameters (K(m) and V(max)) and pharmacokinetic properties of three probe drugs were compared using wild-type and humanized UGT1 mice that express the Gilbert's UGT1A1*28 allele [Tg(UGT1(A1*28))...
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