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Article

Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor.

The Journal of biological chemistry - 19 Jan 2007

Datta-Mannan Amita, Witcher Derrick R, Tang Ying, Watkins Jeffry, Wroblewski Victor J

Abstract excerpt

The neonatal Fc receptor (FcRn) plays a critical role in regulating IgG homeostasis in vivo. There are mixed reports on whether modification of the interaction with FcRn can be used as an engineering strategy to improve the pharmacokinetic and pharmacodynamic properties of monoclonal antibodies. We tested whether the T250Q/M428L mutations, which improved the pharmacokinetics of humanized IgGs in the rhesus...

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Identifiers

PMID: 17135257
DOI: 10.1074/jbc.M607161200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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