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Article

Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor.

mAbs - 1 Jan 2000

Yip Victor, Palma Enzo, Tesar Devin B, Mundo Eduardo E, Bumbaca Daniela, Torres Elizabeth K, Reyes Noe A, Shen Ben Q, Fielder Paul J, Prabhu Saileta, Khawli Leslie A, Boswell C Andrew

Abstract excerpt

The neonatal Fc receptor (FcRn) plays an important and well-known role in antibody recycling in endothelial and hematopoietic cells and thus it influences the systemic pharmacokinetics (PK) of immunoglobulin G (IgG). However, considerably less is known about FcRn's role in the metabolism of IgG within individual tissues after intravenous administration. To elucidate the organ distribution and gain insight into...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24572100
DOI: 10.4161/mabs.28254
PMCID: PMC4011913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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