Article
A Physiologically-Based Pharmacokinetic Model for the Prediction of "Half-Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics.
CPT: pharmacometrics & systems pharmacology - 1 Sept 2020
Jones Hannah M, Tolsma John, Zhang Zhiwei, Jasper Paul, Luo Haobin, Weber Gregory L, Wright Katherine, Bard Joel, Bell Robert, Messing Dean, Kelleher Kerry, Piche-Nicholas Nicole, Webster Robert
Abstract excerpt
Monoclonal antibodies (mAbs) can be engineered to have "extended half-life" and "catch and release" properties to improve target coverage. We have developed a mAb physiologically-based pharmacokinetic model that describes intracellular trafficking, neonatal Fc receptor (FcRn) recycling, and nonspecific clearance of mAbs. We extended this model to capture target binding as a function of target affinity,...
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