Article
Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene.
PloS one - 1 Jan 2015
Yong Carmen S M, Sharkey Janelle, Duscio Belinda, Venville Ben, Wei Wei-Zen, Jones Richard F, Slaney Clare Y, Mir Arnau Gisela, Papenfuss Anthony T, Schröder Jan, Darcy Phillip K, Kershaw Michael H
Abstract excerpt
The development of antigen-targeted therapeutics is dependent on the preferential expression of tumor-associated antigens (TAA) at targetable levels on the tumor. Tumor-associated antigens can be generated de novo or can arise from altered expression of normal basal proteins, such as the up-regulation of human epidermal growth factor receptor 2 (Her2/ErbB2). To properly assess the development of Her2 therapeutics...
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