MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.

doi:10.1073/pnas.1408650111

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Article

MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014

Mohseni Morassa, Cidado Justin, Croessmann Sarah, Cravero Karen, Cimino-Mathews Ashley, Wong Hong Yuen, Scharpf Rob, Zabransky Daniel J, Abukhdeir Abde M, Garay Joseph P, Wang Grace M, Beaver Julia A, Cochran Rory L, Blair Brian G, Rosen D Marc, Erlanger Bracha, Argani Pedram, Hurley Paula J, Lauring Josh, Park Ben Ho

Abstract excerpt

Tamoxifen is effective for treating estrogen receptor-alpha (ER) positive breast cancers. However, few molecular mediators of tamoxifen resistance have been elucidated. Here we describe a previously unidentified gene, MACROD2 that confers tamoxifen resistance and estrogen independent growth. We found MACROD2 is amplified and overexpressed in metastatic tamoxifen-resistant tumors. Transgene overexpression of...

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Identifiers

PMID: 25422431
DOI: 10.1073/pnas.1408650111
PMCID: PMC4267353

Genes

MACROD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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