Article

MORC2/ β-catenin signaling axis promotes proliferation and migration of breast cancer cells

2022-03-28

Abstract excerpt

<title>Abstract</title> <p>Although Microrchidia 2 (MORC2) is overexpressed in many types of human cancer, its role in breast cancer progression remains unknown. Here, we report that the chromatin remodeler MORC2 expression positively correlates with β-catenin expression in breast cancer cell lines and patients. Overexpression of MORC2 augmented the expression of β-catenin and its target genes, cyclin D1 and c-My...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fec2fa54-f85e-550d-a2c8-0ea2658a9d7d
DOI: 10.21203/rs.3.rs-1453593/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MORC2/ β-catenin signaling axis promotes proliferation and migration of breast cancer cellsDOI 10.21203/rs.3.rs-1453593/v1Read

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin SignalingSemantic proximity Read

RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMTSemantic proximity Read

<i>FOXK2</i> amplification and overexpression promotes breast cancer development and chemoresistanceSemantic proximity Read

A novel ER–microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progressionSemantic proximity Read

Abnormal expression of Nek2 and β-catenin in breast carcinoma: clinicopathological correlationsSemantic proximity Read

Overexpression of CDCA7 predicts poor prognosis and induces EZH2‐mediated progression of triple‐negative breast cancerSemantic proximity Read

The Low Expression of MEOX2 is Associated With Poorer Survival in Breast CancerSemantic proximity Read

ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancerSemantic proximity Read

Downregulation of MAL2 inhibits breast cancer progression through regulating β-catenin/c-Myc axisSemantic proximity Read

FOXK2 amplification promotes breast cancer development and chemoresistanceSemantic proximity Read

By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancerSemantic proximity Read

DNMT1 facilitates proliferation and metastasis of breast cancer by inducing MEG3 promoter methylation in MEG3/miR-494-3p/OTUD4 regulatory axisSemantic proximity Read