Article
Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2006
Cui Yukun, Niu Airu, Pestell Richard, Kumar Rakesh, Curran Edward M, Liu Yunde, Fuqua Suzanne A W
Abstract excerpt
Estrogen receptor (ER)alpha activity is controlled by the balance of coactivators and corepressors contained within cells that are recruited into transcriptional complexes. The metastasis-associated protein (MTA) family has been demonstrated to be associated with breast tumor cell progression and ERalpha activity. We demonstrate that MTA2 expression is correlated with ERalpha protein expression in invasive breast...
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