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Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis

30 Mar 2015

Abstract excerpt

Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2–macroH2A1 (mH2A1)–cyclin-dependent kinase 8 (CDK8) axis as a critical pathway for these processes, and deregulation of this pathway is associated with human breast cancer progression and patient survival outcome. We...

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PMID: 25818643
DOI: 10.1038/ncomms7641

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