Article
Interferon regulatory factor 7 participates in the M1-like microglial polarization switch.
Glia - 1 Apr 2015
Tanaka Tatsuhide, Murakami Koichi, Bando Yoshio, Yoshida Shigetaka
Abstract excerpt
Microglia are generally considered the immune cells of the central nervous system. Recent studies have demonstrated that under specific polarization conditions, microglia develop into two different phenotypes, termed M1-like and M2-like microglia. However, the phenotypic characteristics of M1-like- and M2-like-polarized microglia and the mechanisms that regulate polarization are largely unknown. In this study, we...
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