Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization.

Mediators of inflammation - 1 Jan 2016

Cunha Carolina, Gomes Cátia, Vaz Ana Rita, Brites Dora

Abstract excerpt

Identification of mediators triggering microglia activation and transference of noncoding microRNA (miRNA) into exosomes are critical to dissect the mechanisms underlying neurodegeneration. We used lipopolysaccharide- (LPS-) induced N9 microglia activation to explore new biomarkers/signaling pathways and to identify inflammatory miRNA (inflamma-miR) in cells and their derived exosomes. Upregulation of iNOS and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginase
Share to Exosomes
Share to HMGB1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Matrix Metalloproteinase 9

Share to Microglia

Share to Phagocytosis

Share to Receptors, Interleukin-8A

Source

Open in PubMed Open full text

Identifiers

PMID: 28096568
DOI: 10.1155/2016/6986175
PMCID: PMC5209629

Genes

HMGB1
NLRP3
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization.PMID 28096568Read ↗

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia.Semantic proximity Read ↗

Exosomal miRNAs-mediated macrophage polarization and its potential clinical application.Semantic proximity Read ↗

Continuous injection of high-dose lipopolysaccharide modulates microglia polarization via TREM2 to alter the status of septic miceSemantic proximity Read ↗

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signaturesSemantic proximity Read ↗

Identifying functional microRNAs in macrophages with polarized phenotypes.Semantic proximity Read ↗

Interfering PTBP1 expression inducing M2 macrophage polarization via miR-124/MAPK pathwaySemantic proximity Read ↗

Interferon regulatory factor 7 participates in the M1-like microglial polarization switch.Semantic proximity Read ↗

Exosome-shuttled miRNAs contribute to the modulation of the neuroinflammatory microglia phenotype by mesenchymal stem cells. Implication for amyotrophic lateral sclerosisSemantic proximity Read ↗

How microbiota shape microglial phenotypes and epigenetics.Semantic proximity Read ↗

Microglia/macrophage polarization: Fantasy or evidence of functional diversity?Semantic proximity Read ↗

Modulating the polarization phenotype of microglia - A valuable strategy for central nervous system diseases.Semantic proximity Read ↗

Microglia Polarization from M1 toward M2 Phenotype Is Promoted by Astragalus Polysaccharides Mediated through Inhibition of miR-155 in Experimental Autoimmune Encephalomyelitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.