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Article

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.

Immunity - 1 Aug 2007

Moon James J, Chu H Hamlet, Pepper Marion, McSorley Stephen J, Jameson Stephen C, Kedl Ross M, Jenkins Marc K

Abstract excerpt

Cell-mediated immunity stems from the proliferation of naive T lymphocytes expressing T cell antigen receptors (TCRs) specific for foreign peptides bound to host major histocompatibility complex (MHC) molecules. Because of the tremendous diversity of the T cell repertoire, naive T cells specific for any one peptide:MHC complex (pMHC) are extremely rare. Thus, it is not known how many naive T cells of any given...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17707129
DOI: 10.1016/j.immuni.2007.07.007
PMCID: PMC2200089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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