Bohemian T cell receptors: sketching the repertoires of unconventional lymphocytes.

doi:10.1111/imr.12668

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Article

Bohemian T cell receptors: sketching the repertoires of unconventional lymphocytes.

Immunological reviews - 1 Jul 2018

Schattgen Stefan A, Thomas Paul G

Abstract excerpt

Over the last several decades, novel populations of unconventional T cells have been identified; defined by an invariant (or nearly invariant) T cell receptor (TCR) with a fixed specificity to non-canonical antigens and major histocompatibility (MHC) molecules, they form large, functionally monoclonal populations tasked with surveying for their specific antigens. With residence in both lymphoid and non-lymphoid...

Topics

Adaptive Immunity
Animals
Genetic Variation
Humans
Mice
Natural Killer T-Cells
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocyte Subsets

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PMID: 29944761
DOI: 10.1111/imr.12668
PMCID: PMC6128411

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