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Article

Homeostasis of Naive and Memory T Lymphocytes.

Cold Spring Harbor perspectives in biology - 1 Sept 2021

Kawabe Takeshi, Yi Jaeu, Sprent Jonathan

Abstract excerpt

Conventional CD4+ and CD8+ T lymphocytes comprise a mixture of naive and memory cells. Generation and survival of these T-cell subsets is under strict homeostatic control and reflects contact with self-major histocompatibility complex (MHC) and certain cytokines. Naive T cells arise in the thymus via T-cell receptor (TCR)-dependent positive selection to self-peptide/MHC complexes and are then maintained in the...

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PMID: 33753403
DOI: 10.1101/cshperspect.a037879
PMCID: PMC8411951

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