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Article

Cancer somatic mutations cluster in a subset of regulatory sites predicted from the ENCODE data.

Molecular cancer - 25 Nov 2016

Shar Nisar A, Vijayabaskar M S, Westhead David R

Abstract excerpt

BACKGROUND: Transcriptional regulation of gene expression is essential for cellular differentiation and function, and defects in the process are associated with cancer. The ENCODE project has mapped potential regulatory sites across the complete genome in many cell types, and these regions have been shown to harbour many of the somatic mutations that occur in cancer cells, suggesting that their effects may drive...

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Identifiers

PMID: 27887606
DOI: 10.1186/s12943-016-0560-0
PMCID: PMC5123355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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