Article
Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.
Journal of cell science - 15 Jan 2015
Tang Mengfan, Li Yujing, Zhang Yi, Chen Yuxi, Huang Wenjun, Wang Dan, Zaug Arthur J, Liu Dan, Zhao Yong, Cech Thomas R, Ma Wenbin, Songyang Zhou
Abstract excerpt
Most human cancers depend on the telomerase to maintain telomeres; however, about 10% of cancers are telomerase negative and utilize the alternative lengthening of telomeres (ALT) mechanism. Mutations in the DAXX gene have been found frequently in both telomerase-positive and ALT cells, and how DAXX mutations contribute to cancers remains unclear. We report here that endogenous DAXX can localize to Cajal bodies,...
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