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Article

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

29 Jan 2009

Abstract excerpt

Telomerase is a ribonucleoprotein (RNP) complex that synthesizes telomere repeats in tissue progenitor cells and cancer cells. Active human telomerase consists of at least three principal subunits, including the telomerase reverse transcriptase, the telomerase RNA (TERC), and dyskerin. Here, we identify a holoenzyme subunit, TCAB1 (telomerase Cajal body protein 1), that is notably enriched in Cajal bodies,...

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Identifiers

PMID: 19179534
DOI: 10.1126/science.1165357

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Related research

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A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere SynthesisPMID 19179534Read ↗

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Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenanceSemantic proximity Read ↗

Telomerase Recruitment Requires both TCAB1 and Cajal Bodies IndependentlySemantic proximity Read ↗

Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodiesSemantic proximity Read ↗

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