Article
Altered telomeres in tumors with ATRX and DAXX mutations.
Science (New York, N.Y.) - 22 Jul 2011
Heaphy Christopher M, de Wilde Roeland F, Jiao Yuchen, Klein Alison P, Edil Barish H, Shi Chanjuan, Bettegowda Chetan, Rodriguez Fausto J, Eberhart Charles G, Hebbar Sachidanand, Offerhaus G Johan, McLendon Roger, Rasheed B Ahmed, He Yiping, Yan Hai, Bigner Darell D, Oba-Shinjo Sueli Mieko, Marie Suely Kazue Nagahashi, Riggins Gregory J, Kinzler Kenneth W, Vogelstein Bert, Hruban Ralph H, Maitra Anirban, Papadopoulos Nickolas, Meeker Alan K
Abstract excerpt
The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres and other genomic sites. Because inactivating mutations of these genes are common in human pancreatic neuroendocrine tumors (PanNETs), we examined the telomere status of these tumors. We found that 61% of PanNETs displayed abnormal telomeres that are characteristic of a telomerase-independent telomere maintenance mechanism...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.