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Article

The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) Phenotype

19 Sept 2016

Abstract excerpt

Telomeres are responsible for protecting chromosome ends in order to prevent the loss of coding DNA. Their maintenance is required for achieving immortality by neoplastic cells and can occur by upregulation of the telomerase enzyme or through a homologous recombination-associated process, the alternative lengthening of telomeres (ALT). The precise mechanisms that govern the activation of ALT or telomerase in...

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Share to DNA Repair Mechanisms
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PMID: 27657132
DOI: 10.3390/genes7090066

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