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Article

Compromised Telomeric Heterochromatin Promotes ALTernative Lengthening of Telomeres.

Trends in cancer - 1 Mar 2016

Voon Hsiao P J, Collas Philippe, Wong Lee H

Abstract excerpt

Alternative lengthening of telomeres (ALT) is an enigmatic process that allows certain cancers to maintain telomeres in the absence of telomerase. ALT cancers are frequently defective for ATRX/DAXX, a chaperone complex that deposits histone variant H3.3 at telomeres. We propose that mutations in alpha thalassemia-mental retardation syndrome X-linked (ATRX)/death-domain associated protein (DAXX) prime ALT...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28741530
DOI: 10.1016/j.trecan.2016.02.003

Genes

ATRX
DAXX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Compromised Telomeric Heterochromatin Promotes ALTernative Lengthening of Telomeres.PMID 28741530Read ↗

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Altered telomeres in tumors with ATRX and DAXX mutations.Semantic proximity Read ↗

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific mannerSemantic proximity Read ↗

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