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Article

Cancer-Associated DAXX Mutations Reveal a Critical Role for ATRX Localization in ALT Suppression.

Molecular and cellular biology - 1 Jan 2026

Clatterbuck Soper Sarah F, Walker Robert L, Pineda Marbin A, Zhu Yuelin J, Dalgleish James L T, Wang Jasmine, Meltzer Paul S

Abstract excerpt

To maintain genome stability, proliferating cells must enact a program of telomere maintenance. While most tumors maintain telomeres using telomerase, a subset of tumors utilize a DNA-templated process termed alternative lengthening of telomeres or ALT. ALT is associated with mutations in the ATRX/DAXX/H3.3 histone chaperone complex, which is responsible for deposition of histone variant H3.3 at heterochromatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41424059
DOI: 10.1080/10985549.2025.2597468

Genes

DAXX
ATRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Cancer-Associated DAXX Mutations Reveal a Critical Role for ATRX Localization in ALT Suppression.PMID 41424059Read ↗

Cancer-associated DAXX mutations reveal a critical role for ATRX localization in ALT suppressionSemantic proximity Read ↗

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Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres PathwaySemantic proximity Read ↗

Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.Semantic proximity Read ↗

Compromised Telomeric Heterochromatin Promotes ALTernative Lengthening of Telomeres.Semantic proximity Read ↗

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific mannerSemantic proximity Read ↗

The Chromatin Remodeler ATRX: Role and Mechanism in Biology and CancerSemantic proximity Read ↗

ATRX and DAXX: Mechanisms and Mutations.Semantic proximity Read ↗

Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas.Semantic proximity Read ↗

ALT Positivity in Human Cancers: Prevalence and Clinical InsightsSemantic proximity Read ↗

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