Article

Cancer-associated DAXX mutations reveal a critical role for ATRX localization in ALT suppression

2024-11-20

Abstract excerpt

To maintain genome stability, proliferating cells must enact a program of telomere maintenance. While most tumors maintain telomeres through the action of telomerase, a subset of tumors utilize a DNA-templated process termed Alternative Lengthening of Telomeres or ALT. ALT is associated with mutations in the ATRX/DAXX/H3.3 histone chaperone complex, which is responsible for deposition of non-replicative histone va...

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Literature Corpus work: 9ec2f443-314b-5344-a65d-f9dc9820f0ae
DOI: 10.1101/2024.11.18.624165

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