Article
CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populations.
Carcinogenesis - 1 Jan 2015
Wassenaar Catherine A, Ye Yuanqing, Cai Qiuyin, Aldrich Melinda C, Knight Joanne, Spitz Margaret R, Wu Xifeng, Blot William J, Tyndale Rachel F
Abstract excerpt
We investigated genetic variation in CYP2A6 in relation to lung cancer risk among African American smokers, a high-risk population. Previously, we found that CYP2A6, a nicotine/nitrosamine metabolism gene, was associated with lung cancer risk in European Americans, but smoking habits, lung cancer risk and CYP2A6 gene variants differ significantly between European and African ancestry populations. Herein, African...
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