The degree of N-glycosylation affects the trafficking and cell surface expression levels of Kv1.4 potassium channels.

doi:10.1007/s00232-014-9756-7

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Article

The degree of N-glycosylation affects the trafficking and cell surface expression levels of Kv1.4 potassium channels.

The Journal of membrane biology - 1 Apr 2015

Watanabe Itaru, Zhu Jing, Recio-Pinto Esperanza, Thornhill William B

Abstract excerpt

Kv1.4 potassium channels are heavily glycosylated proteins involved in shaping action potentials and in neuronal excitability and plasticity. Kv1.4 N354Q, without an N-glycan, exhibited decreased protein stability and trafficking to the cell surface (Watanabe et al. in J Biol Chem 279:8879-8885, 2004). Here we investigated whether the composition of the N-glycan affected Kv1.4 cell surface expression. Kv1.4...

Topics

Animals
CHO Cells
Cell Membrane
Cricetulus
Endoplasmic Reticulum
Enzyme Inhibitors
Gene Expression
Glycoside Hydrolases
Glycosylation
Kv1.4 Potassium Channel
Mannose
Mutation
Polysaccharides
Protein Folding
Protein Multimerization
Protein Transport

Source

Open in PubMed

Identifiers

PMID: 25416425
DOI: 10.1007/s00232-014-9756-7

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