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Article

O-glycosylation of the cardiac I(Ks) complex.

The Journal of physiology - 1 Aug 2011

Chandrasekhar Kshama D, Lvov Anatoli, Terrenoire Cecile, Gao Grace Y, Kass Robert S, Kobertz William R

Abstract excerpt

Post-translational modifications of the KCNQ1–KCNE1 (Kv7) K+ channel complex are vital for regulation of the cardiac IKs current and action potential duration. Here, we show the KCNE1 regulatory subunit is O-glycosylated with mucin-type glycans in vivo. As O-linked glycosylation sites are not recognizable by sequence gazing, we designed a novel set of glycosylation mutants and KCNE chimeras and analysed their...

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Source

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Identifiers

PMID: 21669976
DOI: 10.1113/jphysiol.2011.211284
PMCID: PMC3171881

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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