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Article

Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states.

Biochimica et biophysica acta - 1 Jun 2015

Mercier Aurélie, Clément Romain, Harnois Thomas, Bourmeyster Nicolas, Bois Patrick, Chatelier Aurélien

Abstract excerpt

BACKGROUND: Like many voltage-gated sodium channels, the cardiac isoform Nav1.5 is well known as a glycoprotein which necessarily undergoes N-glycosylation processing during its transit to the plasma membrane. In some cardiac disorders, especially the Brugada syndrome (BrS), mutations in Nav1.5 encoding gene lead to intracellular retention and consequently trafficking defect of these proteins. We used two BrS...

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Identifiers

PMID: 25721215
DOI: 10.1016/j.bbagen.2015.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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