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Article

N-linked glycans are required on epithelial Na+ channel subunits for maturation and surface expression.

American journal of physiology. Renal physiology - 1 Mar 2018

Kashlan Ossama B, Kinlough Carol L, Myerburg Michael M, Shi Shujie, Chen Jingxin, Blobner Brandon M, Buck Teresa M, Brodsky Jeffrey L, Hughey Rebecca P, Kleyman Thomas R

Abstract excerpt

Epithelial Na+ channel (ENaC) subunits undergo N-linked glycosylation in the endoplasmic reticulum where they assemble into an αβγ complex. Six, 13, and 5 consensus sites (Asn-X-Ser/Thr) for N-glycosylation reside in the extracellular domains of the mouse α-, β-, and γ-subunits, respectively. Because the importance of ENaC N-linked glycans has not been fully addressed, we examined the effect of preventing...

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Identifiers

PMID: 29187368
DOI: 10.1152/ajprenal.00195.2017
PMCID: PMC5899221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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