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Article

Novel insights into vascularization patterns and angiogenic factors in glioblastoma subclasses.

Journal of neuro-oncology - 1 Jan 2017

Conroy Siobhan, Wagemakers Michiel, Walenkamp Annemiek M E, Kruyt Frank A E, den Dunnen Wilfred F A

Abstract excerpt

Glioblastoma (GBM) is a highly vascularized and aggressive type of primary brain tumor in adults with dismal survival. Molecular subtypes of GBM have been identified that are related to clinical outcome and response to therapy. Although the mesenchymal type has been ascribed higher angiogenic activity, extensive characterization of the vascular component in GBM subtypes has not been performed. Therefore, we aimed...

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Source

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Identifiers

PMID: 27633774
DOI: 10.1007/s11060-016-2269-8
PMCID: PMC5258811

Genes

ANGPT2
IDH1
MMP2
MMP9
TIMP1
TIMP2
VEGFA

Provenance

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