Hypomethylation and overexpression of ITGAL (CD11a) in CD4+ T cells in systemic sclerosis

Abstract excerpt

BACKGROUND: The pathogenesis and etiology of systemic sclerosis (SSc) are complex and poorly understood. To date, several studies have demonstrated that the activation of the immune system undoubtedly plays a pivotal role in SSc pathogenesis. Activated immune effector T cells contribute to the release of various pro-inflammatory cytokines and drive the SSc-specific autoantibody responses. This, and a profibrotic...

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